Reading Domenico Bertoloni-Meli Mechanism, Experiment, Disease:Marcello Malpighi and Seventeenth-century anatomy I came across this image, one of the first printed images of the microstructure of an organ. It shows I. a network covering external vesicles, II. a few internal vesicles and III. different modes of insertion of the pulmonary lobules. These are from his Malpighi's tow Epistolae of 1661.